VAMCA ("Visualization And Meta-analysis on Cortical Anatomy") is an open source meta-analysis, visualization, and significance testing toolbox for MatLab, and it can be run on many kinds of hardware.  It is a command-line program that can be used to display MNI or Talairach coordinates on a mean cortical surface displayed in any one of 4 views. Two groups of coordinates can be displayed on the surface and they can be tested to see if they are not in the same location or in the same regions of interests.  The stand-alone toolbox works with Matlab versions 5.3-7.x and requires 500 MB of free disk space. 

Briefly, the VAMCA Toolbox does the following:

1) Multi-Fiducial Mapping: Map a normalized 3D coordinate to the cortical location in each of 60 subjects and view on one map.

2) Computing Median Locations for groups of foci on a mean cortex and in MNI-152 space.

3) Comparing Two Groups of Foci for differences in location of their centroids.

4) Detecting Significant Densities of Foci within 2 classes of ROIs on a mean cortical surface.

5) Detecting Density Differences of Foci Groups in order to detect activation differences within ROIs.

6) Comparisons of Groups of Foci Across Hemispheres.

The newest version of the software is being distributed at the NITRC website

Timothy Herron, HCN Laboratory, UC Davis & VANCHCS, Martinez, CA, USA